Fish in a dish: drug discovery for hearing habilitation
نویسندگان
چکیده
منابع مشابه
Fish in a Dish: Drug Discovery for Hearing Habilitation.
The majority of hearing loss is caused by the permanent loss of inner ear hair cells. The identification of drugs that modulate the susceptibility to hair cell loss or spur their regeneration is often hampered by the difficulties of assaying for such complex phenomena in mammalian models. The zebrafish has emerged as a powerful animal model for chemical screening in many contexts. Several chara...
متن کاملHearing aids re-habilitation in aged people
Presbyacusis is defined as the cumulative effects of aging on hearing ability. Each of them commonly feature different impairments, e.g on: sound hearing (mostly for high frequencies), speech understanding (mostly in noise), delayed speech processing by NCS and sound source localization. Its fuzzy and unclear simptomatology frequently leads to a delayed detection. In addition, the affected subj...
متن کاملMuscular dystrophy in a dish: engineered human skeletal muscle mimetics for disease modeling and drug discovery.
Engineered in vitro models using human cells, particularly patient-derived induced pluripotent stem cells (iPSCs), offer a potential solution to issues associated with the use of animals for studying disease pathology and drug efficacy. Given the prevalence of muscle diseases in human populations, an engineered tissue model of human skeletal muscle could provide a biologically accurate platform...
متن کاملKnowledge Discovery and Data Mining in Biomedicine Thesis for Habilitation
In high-dimensional feature spaces traditional clustering algorithms tend to break down in terms of efficiency and quality. Nevertheless, the data sets often contain clusters which are hidden in various subspaces of the original feature space. In this paper, we present a feature selection technique called SURFING (SUbspaces Relevant For clusterING) that finds all subspaces interesting for clust...
متن کاملEthnobotany, Ethnopharmacology and Drug Discovery
This manuscript is a review of a number of ethnobotany and ethnopharmacology texts and papers in order to arrive at current understanding and scope of ethnobotany and ethnopharmacology. It includes either a brief definition of both fields and presenting some examples on them. Also it has a glimpse on the geographical coverage of research works throughout the world, important issue of prope...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Drug Discovery Today: Disease Models
سال: 2013
ISSN: 1740-6757
DOI: 10.1016/j.ddmod.2012.02.001